Varaico: Literature-Extracted Genetic Variants

CD4

453 papers

RefSeq Summary

This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presen...

Pfam Domains

igaa 27–122UCSCImmunoglobulin domain

C2-setaa 125–203UCSCImmunoglobulin C2-set domain

CD4-extracelaa 206–316UCSCCD4, extracellular

C2-setaa 317–390UCSCImmunoglobulin C2-set domain

Tcell_CD4_Caa 402–449UCSCT cell CD4 receptor C terminal region

Gene Aliases

HGNC Name

CD4 molecule

HGNC Alias Symbols

T4; Leu-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000616.5

p.C422W

c.1266C>G

Surrounding Variants

2 papers

NM_000616.5

p.R423W

c.1267C>T

2 papers

NM_000616.5

p.C422S

c.1265G>C

1 paper

NM_000616.5

p.R423Q

c.1268G>A

2 papers

NM_000616.5

p.C422S

c.1264T>A

2 papers

NM_000616.5

p.R425Q

c.1274G>A

1 paper

NM_000616.5

p.V420I

c.1258G>A

2 papers

NM_000616.5

p.R426insFs

c.1277_1278insA

4 papers

NM_000616.5

p.R426_R427Splc

c.1278+1G>A

1 paper

NM_000616.5

p.R426_R427Splc

c.1278+3G>C

1 paper

NM_000616.5

p.R426_R427Splc

c.1278+5G>A

1 paper

NM_000616.5

p.L414delFs

c.1240delC

1 paper

NM_000616.5

p.I412T

c.1235T>C