Varaico: Literature-Extracted Genetic Variants

Gene:CD80
Variant:p.R224T

CD80

281 papers

RefSeq Summary

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can...

Pfam Domains

V-setaa 36–137UCSCImmunoglobulin V-set domain
C2-set_2aa 141–227UCSCCD80-like C2-set immunoglobulin domain

Gene Aliases

HGNC Name

CD80 molecule

HGNC Previous Symbols

CD28LG; CD28LG1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005191.4
p.R224T
c.671G>C
Surrounding Variants
3 papers
NM_005191.4
p.H222Y
c.664C>T
3 papers
NM_005191.4
p.Q227*
c.679C>T
1 paper
NM_005191.4
p.G221E
c.662G>A
1 paper
NM_005191.4
p.Y220H
c.658T>C
1 paper
NM_005191.4
p.F229Y
c.686T>A
1 paper
NM_005191.4
p.I218I
c.654C>T
1 paper
NM_005191.4
p.N230S
c.689A>G
1 paper
NM_005191.4
p.W231R
c.691T>C
1 paper
NM_005191.4
p.N232insFs
c.694_695insC
1 paper
NM_005191.4
p.N232insFs
c.695_696insC
1 paper
NM_005191.4
p.N232N
c.696T>C
1 paper
NM_005191.4
p.M215R
c.644T>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."