Varaico: Literature-Extracted Genetic Variants

Gene:CD80
Variant:p.T187R

CD80

281 papers

RefSeq Summary

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can...

Pfam Domains

V-setaa 36–137UCSCImmunoglobulin V-set domain
C2-set_2aa 141–227UCSCCD80-like C2-set immunoglobulin domain

Gene Aliases

HGNC Name

CD80 molecule

HGNC Previous Symbols

CD28LG; CD28LG1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005191.4
p.T187R
c.560C>G
Surrounding Variants
1 paper
NM_005191.4
p.T187K
c.560C>A
1 paper
NM_005191.4
p.T187_T188insFs
c.561_562ins5
1 paper
NM_005191.4
p.N186D
c.556A>G
1 paper
NM_005191.4
p.N183D
c.547A>G
1 paper
NM_005191.4
p.Q191delFs
c.573delT
1 paper
NM_005191.4
p.P193A
c.577C>G
1 paper
NM_005191.4
p.P193R
c.578C>G
1 paper
NM_005191.4
p.T195I
c.584C>T
1 paper
NM_005191.4
p.V200D
c.599T>A
1 paper
NM_005191.4
p.S174C
c.521C>G
2 papers
NM_005191.4
p.S201G
c.601A>G
1 paper
NM_005191.4
p.L173F
c.517C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."