Varaico: Literature-Extracted Genetic Variants

Gene:CD80
Variant:p.I36F

CD80

281 papers

RefSeq Summary

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can...

Pfam Domains

V-setaa 36–137UCSCImmunoglobulin V-set domain
C2-set_2aa 141–227UCSCCD80-like C2-set immunoglobulin domain

Gene Aliases

HGNC Name

CD80 molecule

HGNC Previous Symbols

CD28LG; CD28LG1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_005191.4
p.I36F
c.106A>T
Surrounding Variants
2 papers
NM_005191.4
p.V42M
c.124G>A
1 paper
NM_005191.4
p.V45V
c.135G>A
1 paper
NM_005191.4
p.T47A
c.139A>G
1 paper
NM_005191.4
p.L48P
c.143T>C
1 paper
NM_005191.4
p.C50F
c.149G>T
2 papers
NM_005191.4
p.E58D
c.174G>C
1 paper
NM_005191.4
p.Q61E
c.181C>G
1 paper
NM_005191.4
p.R63G
c.187C>G
1 paper
NM_005191.4
p.R63S
c.187C>A
1 paper
NM_005191.4
p.R63H
c.188G>A
1 paper
NM_005191.4
p.I64L
c.190A>C
1 paper
NM_005191.4
p.E69K
c.205G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."