Varaico: Literature-Extracted Genetic Variants

CDC42BPB

133 papers

RefSeq Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this p...

Pfam Domains

Pkinaseaa 76–342UCSCProtein kinase domain

KELKaa 527–606UCSCKELK-motif containing domain of MRCK Ser/Thr protein kinase

DMPK_coilaa 878–939UCSCDMPK coiled coil domain like

C1_1aa 1026–1078UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PH_MRCKaa 1089–1215UCSCMRCK kinase PH domain

CNHaa 1250–1509UCSCCNH domain

Gene Aliases

HGNC Name

CDC42 binding protein kinase beta

HGNC Alias Symbols

MRCKB; KIAA1124

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006035.4

p.T906N

c.2717C>A

Surrounding Variants

1 paper

NM_006035.4

p.S909Splc

c.2726+1G>A

1 paper

NM_006035.4

p.V893A

c.2678T>C

1 paper

NM_006035.4

p.A885V

c.2654C>T

2 papers

NM_006035.4

p.R876P

c.2627G>C

2 papers

NM_006035.4

p.R876W

c.2626C>T

2 papers

NM_006035.4

p.L871P

c.2612T>C

1 paper

NM_006035.4

p.Q869insFs

c.2605dupC

2 papers

NM_006035.4

p.R867C

c.2599C>T

1 paper

NM_006035.4

p.K930E

c.2788A>G

1 paper

NM_006035.4

p.K935N

c.2805A>T

1 paper

NM_006035.4

p.K935N

c.2805A>C

2 papers

NM_006035.4

p.L859Q

c.2576T>A