Varaico: Literature-Extracted Genetic Variants

CDC6

139 papers

RefSeq Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps...

Pfam Domains

AAA_16aa 171–314UCSCAAA ATPase domain

Cdc6-ORC-like_ATPase_lidaa 346–405UCSCCdc6/ORC-like, ATPase lid domain

WHD_Cdc6aa 452–544UCSCCDC6, C terminal winged helix domain

Gene Aliases

HGNC Name

cell division cycle 6

HGNC Previous Symbol

CDC18L

Papers

RefSeq ID

Protein change

DNA change

1–12 of 72 variants

11 papers

NM_001254.4

p.V441I

c.1321G>A

10 papers

NM_001254.4

p.D295N

c.883G>A

10 papers

NM_001254.4

p.T323R

c.968C>G

5 papers

NM_001254.4

p.K114E

c.340A>G

3 papers

NM_001254.4

p.T238A

c.712A>G

3 papers

NM_001254.4

p.T299M

c.896C>T

2 papers

NM_001254.4

p.K77R

c.230A>G

2 papers

NM_001254.4

p.Q78*

c.232C>T

2 papers

NM_001254.4

p.Q158*

c.472C>T

1 paper

NM_001254.4

p.M1T

c.2T>C

1 paper

NM_001254.4

p.P2H

c.5C>A

1 paper

NM_001254.4

p.P2P

c.6T>A