Varaico: Literature-Extracted Genetic Variants

CDC6

139 papers

RefSeq Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps...

Pfam Domains

AAA_16aa 171–314UCSCAAA ATPase domain

Cdc6-ORC-like_ATPase_lidaa 346–405UCSCCdc6/ORC-like, ATPase lid domain

WHD_Cdc6aa 452–544UCSCCDC6, C terminal winged helix domain

Gene Aliases

HGNC Name

cell division cycle 6

HGNC Previous Symbol

CDC18L

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001254.4

p.V147E

c.440T>A

Surrounding Variants

1 paper

NM_001254.4

p.I120I

c.360A>T

1 paper

NM_001254.4

p.K114Q

c.340A>C

5 papers

NM_001254.4

p.K114E

c.340A>G

1 paper

NM_001254.4

p.L112L

c.334C>T

1 paper

NM_001254.4

p.P107A

c.319C>G

1 paper

NM_001254.4

p.S106A

c.316T>G

1 paper

NM_001254.4

p.K105M

c.314A>T

1 paper

NM_001254.4

p.C156Y

c.467G>A

2 papers

NM_001254.4

p.Q158*

c.472C>T

1 paper

NM_001254.4

p.A160T

c.478G>A

1 paper

NM_001254.4

p.V163F

c.487G>T

1 paper

NM_001254.4

p.G84S

c.250G>A