Varaico: Literature-Extracted Genetic Variants

CDC6

139 papers

RefSeq Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps...

Pfam Domains

AAA_16aa 171–314UCSCAAA ATPase domain

Cdc6-ORC-like_ATPase_lidaa 346–405UCSCCdc6/ORC-like, ATPase lid domain

WHD_Cdc6aa 452–544UCSCCDC6, C terminal winged helix domain

Gene Aliases

HGNC Name

cell division cycle 6

HGNC Previous Symbol

CDC18L

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001254.4

p.C156Y

c.467G>A

Surrounding Variants

2 papers

NM_001254.4

p.Q158*

c.472C>T

1 paper

NM_001254.4

p.A160T

c.478G>A

1 paper

NM_001254.4

p.V163F

c.487G>T

1 paper

NM_001254.4

p.V168I

c.502G>A

1 paper

NM_001254.4

p.R171W

c.511C>T

1 paper

NM_001254.4

p.V181A

c.542T>C

1 paper

NM_001254.4

p.I190_G192delFs

c.569_576del8

1 paper

NM_001254.4

p.S197fs

c.589_590fs

1 paper

NM_001254.4

p.L198I

c.592C>A

1 paper

NM_001254.4

p.Y199H

c.595T>C

1 paper

NM_001254.4

p.V147E

c.440T>A

1 paper

NM_001254.4

p.R214insFs

c.642dupG