carboxylesterase 5A

CES7

FLJ31547

CES4C1

CES5

CAUXIN

carboxylesterase 7

Carboxylesterase 5A

Carboxylesterase-like urinary excreted protein homolog

Cauxin

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

Varaico: Literature-Extracted Genetic Variants

CES5A

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol