ChaC glutathione specific gamma-glutamylcyclotransferase 1

MGC4504

ChaC, cation transport regulator homolog 1 (E. coli)

gamma-GCT acting on glutathione homolog 1

Glutathione-specific gamma-glutamylcyclotransferase 1

Blocks Notch protein

Cation transport regulator-like protein 1

Gamma-GCG 1

Botch

This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016].

Varaico: Literature-Extracted Genetic Variants

CHAC1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol