charged multivesicular body protein 4C

MGC22825

Shax3

VPS32C

chromatin modifying protein 4C

Snf7 homologue associated with Alix 3

Charged multivesicular body protein 4c

Chromatin-modifying protein 4c

SNF7 homolog associated with Alix 3

SNF7-3

Vacuolar protein sorting-associated protein 32-3

CHMP4c

hSnf7-3

Vps32-3

hVps32-3

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].

Varaico: Literature-Extracted Genetic Variants

CHMP4C

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols