chimerin 2

RhoGAP3

chimerin (chimaerin) 2

beta chimerin

chimaerin 2

Beta-chimaerin

Beta-chimerin

Rho GTPase-activating protein 3

Phorbol esters/diacylglycerol binding domain (C1 domain)

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014].

Varaico: Literature-Extracted Genetic Variants

CHN2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol