chloride intracellular channel 2

XAP121

CLCNL2

Chloride intracellular channel protein 2

Glutaredoxin-like oxidoreductase CLIC2

Glutaredoxin-like peroxidase CLIC2

Glutathione S-transferase, C-terminal domain

This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. This protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017].

Varaico: Literature-Extracted Genetic Variants

CLIC2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols