COP9 signalosome subunit 4

CSN4

SGN4

COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 4

COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)

COP9 signalosome complex subunit 4

JAB1-containing signalosome subunit 4

Signalosome subunit 4

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

Varaico: Literature-Extracted Genetic Variants

COPS4

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols