cAMP responsive element modulator

hCREM-2

cAMP-responsive element modulator

Inducible cAMP early repressor

ICER

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

CREM

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol