Varaico: Literature-Extracted Genetic Variants

CRKL

134 papers

RefSeq Summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent...

Pfam Domains

SH2aa 14–88UCSCSH2 domain

SH3_1aa 129–175UCSCSH3 domain

SH3_2aa 239–294UCSCVariant SH3 domain

Gene Aliases

HGNC Name

CRK like proto-oncogene, adaptor protein

HGNC Previous Name

v-crk avian sarcoma virus CT10 oncogene homolog-like

Papers

RefSeq ID

Protein change

DNA change

1–12 of 96 variants

5 papers

NM_005207.4

p.E278K

c.832G>A

4 papers

NM_005207.4

p.R164Q

c.491G>A

3 papers

NM_005207.4

p.Q297*

c.889C>T

2 papers

NM_005207.4

p.Y105*

c.315T>A

2 papers

NM_005207.4

p.S114L

c.341C>T

2 papers

NM_005207.4

p.N117K

c.351C>A

2 papers

NM_005207.4

p.N117K

c.351C>G

2 papers

NM_005207.4

p.Y177F

c.530A>T

2 papers

NM_005207.4

p.R282H

c.845G>A

2 papers

NM_005207.4

p.L285H

c.854T>A

2 papers

NM_005207.4

p.V291fs

c.871_872fs

1 paper

NM_005207.4

p.S3F

c.8C>T