Varaico: Literature-Extracted Genetic Variants

CRKL

134 papers

RefSeq Summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent...

Pfam Domains

SH2aa 14–88UCSCSH2 domain

SH3_1aa 129–175UCSCSH3 domain

SH3_2aa 239–294UCSCVariant SH3 domain

Gene Aliases

HGNC Name

CRK like proto-oncogene, adaptor protein

HGNC Previous Name

v-crk avian sarcoma virus CT10 oncogene homolog-like

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005207.4

p.G46W

c.136G>T

Surrounding Variants

1 paper

NM_005207.4

p.P45L

c.134C>T

1 paper

NM_005207.4

p.S42fs

c.124_125fs

1 paper

NM_005207.4

p.E54K

c.160G>A

1 paper

NM_005207.4

p.E54D

c.162G>C

1 paper

NM_005207.4

p.E54D

c.162G>T

1 paper

NM_005207.4

p.N55_S56ins2

c.165_166ins6

1 paper

NM_005207.4

p.Q31*

c.91C>T

1 paper

NM_005207.4

p.Y61F

c.182A>T

1 paper

NM_005207.4

p.T26I

c.77C>T

1 paper

NM_005207.4

p.T26A

c.76A>G

1 paper

NM_005207.4

p.Q25R

c.74A>G

1 paper

NM_005207.4

p.S20S

c.60T>C