Varaico: Literature-Extracted Genetic Variants

CRKL

134 papers

RefSeq Summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent...

Pfam Domains

SH2aa 14–88UCSCSH2 domain

SH3_1aa 129–175UCSCSH3 domain

SH3_2aa 239–294UCSCVariant SH3 domain

Gene Aliases

HGNC Name

CRK like proto-oncogene, adaptor protein

HGNC Previous Name

v-crk avian sarcoma virus CT10 oncogene homolog-like

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005207.4

p.V113D

c.338T>A

Surrounding Variants

1 paper

NM_005207.4

p.S114*

c.341C>A

1 paper

NM_005207.4

p.S114*

c.341C>G

2 papers

NM_005207.4

p.S114L

c.341C>T

2 papers

NM_005207.4

p.N117K

c.351C>A

2 papers

NM_005207.4

p.N117K

c.351C>G

2 papers

NM_005207.4

p.Y105*

c.315T>A

1 paper

NM_005207.4

p.R129W

c.385C>T

1 paper

NM_005207.4

p.T130insFs

c.388_389insGA

1 paper

NM_005207.4

p.P135S

c.403C>T

1 paper

NM_005207.4

p.G136R

c.406G>C

1 paper

NM_005207.4

p.G136E

c.407G>A

1 paper

NM_005207.4

p.A139T

c.415G>A