Varaico: Literature-Extracted Genetic Variants

CRKL

134 papers

RefSeq Summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent...

Pfam Domains

SH2aa 14–88UCSCSH2 domain

SH3_1aa 129–175UCSCSH3 domain

SH3_2aa 239–294UCSCVariant SH3 domain

Gene Aliases

HGNC Name

CRK like proto-oncogene, adaptor protein

HGNC Previous Name

v-crk avian sarcoma virus CT10 oncogene homolog-like

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005207.4

p.R183*

c.547A>T

Surrounding Variants

1 paper

NM_005207.4

p.K180K

c.540G>A

1 paper

NM_005207.4

p.G188R

c.562G>A

1 paper

NM_005207.4

p.G188R

c.562G>C

2 papers

NM_005207.4

p.Y177F

c.530A>T

1 paper

NM_005207.4

p.S195F

c.584C>T

1 paper

NM_005207.4

p.Y198insFs

c.593dupA

1 paper

NM_005207.4

p.Y198F

c.593A>T

1 paper

NM_005207.4

p.Y198*

c.594T>A

1 paper

NM_005207.4

p.Y198*

c.594T>G

1 paper

NM_005207.4

p.N165_K166ins6

c.493_497ins18

4 papers

NM_005207.4

p.R164Q

c.491G>A

1 paper

NM_005207.4

p.P203R

c.608C>G