Varaico: Literature-Extracted Genetic Variants

CRKL

134 papers

RefSeq Summary

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent...

Pfam Domains

SH2aa 14–88UCSCSH2 domain

SH3_1aa 129–175UCSCSH3 domain

SH3_2aa 239–294UCSCVariant SH3 domain

Gene Aliases

HGNC Name

CRK like proto-oncogene, adaptor protein

HGNC Previous Name

v-crk avian sarcoma virus CT10 oncogene homolog-like

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005207.4

p.A242S

c.724G>T

Surrounding Variants

1 paper

NM_005207.4

p.I243V

c.727A>G

1 paper

NM_005207.4

p.R246K

c.737G>A

1 paper

NM_005207.4

p.V247insFs

c.740dupT

1 paper

NM_005207.4

p.N235D

c.703A>G

1 paper

NM_005207.4

p.Y251F

c.752A>T

1 paper

NM_005207.4

p.S232Y

c.695C>A

1 paper

NM_005207.4

p.P231S

c.691C>T

1 paper

NM_005207.4

p.I227V

c.679A>G

1 paper

NM_005207.4

p.S222F

c.665C>T

1 paper

NM_005207.4

p.S220P

c.658T>C

1 paper

NM_005207.4

p.T213I

c.638C>T

1 paper

NM_005207.4

p.Q211E

c.631C>G