Varaico: Literature-Extracted Genetic Variants

Gene:CUL3
Variant:p.V446delFs

CUL3

494 papers

RefSeq Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core compo...

Pfam Domains

Cullinaa 34–484UCSCCullin alpha solenoid domain
Cullin_ABaa 507–665UCSCCullin alpha+beta domain
Cullin_Nedd8aa 698–760UCSCCullin protein neddylation domain

Gene Aliases

HGNC Name

cullin 3

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003590.5
p.V446delFs
c.1336_1337delAC
Surrounding Variants
1 paper
NM_001257198.2
p.V452delFs
c.1354delC
1 paper
NM_003590.5
p.V446fs
c.1336_1337fs
2 papers
NM_003590.5
p.N443_S445delFs
c.1329_1333del5
1 paper
NM_003590.5
p.N443_K444delFs
c.1329_1332del4
1 paper
NM_003590.5
p.N443fs
c.1327_1328fs
1 paper
NM_003590.5
p.V446_S450delFs
c.1336_1348del13
1 paper
NM_003590.5
p.S450delFs
c.1349delG
1 paper
NM_003590.5
p.E451*
c.1351G>T
1 paper
NM_003590.5
p.E451K
c.1351G>A
2 papers
NM_003590.5
p.S450delFs
c.1349_1350delAG
1 paper
NM_003590.5
p.T442R
c.1325C>G
1 paper
NM_003590.5
p.D449_E451delFs
c.1347_1351del5
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