Varaico: Literature-Extracted Genetic Variants

Gene:CUL3
Variant:p.M287I

CUL3

494 papers

RefSeq Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core compo...

Pfam Domains

Cullinaa 34–484UCSCCullin alpha solenoid domain
Cullin_ABaa 507–665UCSCCullin alpha+beta domain
Cullin_Nedd8aa 698–760UCSCCullin protein neddylation domain

Gene Aliases

HGNC Name

cullin 3

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003590.5
p.M287I
c.861G>C
Surrounding Variants
1 paper
NM_003590.5
p.M287I
c.861G>T
1 paper
NM_003590.5
p.M287I
c.861G>A
1 paper
NM_003590.5
p.M287L
c.859A>T
1 paper
NM_003590.5
p.H286delFs
c.856delG
1 paper
NM_003590.5
p.H286fs
c.856_857fs
8 papers
NM_003590.5
p.V285A
c.854T>C
1 paper
NM_003590.5
p.V285E
c.854T>A
1 paper
NM_003590.5
p.G283V
c.848G>T
1 paper
NM_003590.5
p.G283E
c.848G>A
2 papers
NM_003590.5
p.G283R
c.847G>C
2 papers
NM_003590.5
p.G283R
c.847G>A
1 paper
NM_003590.5
p.T293_E294Fs
c.879_880delinsAFs
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."