Varaico: Literature-Extracted Genetic Variants

Gene:CUL3
Variant:p.I276V

CUL3

494 papers

RefSeq Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core compo...

Pfam Domains

Cullinaa 34–484UCSCCullin alpha solenoid domain
Cullin_ABaa 507–665UCSCCullin alpha+beta domain
Cullin_Nedd8aa 698–760UCSCCullin protein neddylation domain

Gene Aliases

HGNC Name

cullin 3

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003590.5
p.I276V
c.826A>G
Surrounding Variants
2 papers
NM_003590.5
p.I276fs
c.826_827fs
1 paper
NM_003590.5
p.I276fs
c.826_827fs
1 paper
NM_003590.5
p.V277I
c.829G>A
2 papers
NM_003590.5
p.I276delFs
c.827_828delTA
2 papers
NM_003590.5
p.E278A
c.833A>C
1 paper
NM_003590.5
p.E280D
c.840G>C
2 papers
NM_003590.5
p.G283R
c.847G>C
2 papers
NM_003590.5
p.G283R
c.847G>A
1 paper
NM_003590.5
p.G283V
c.848G>T
1 paper
NM_003590.5
p.G283E
c.848G>A
1 paper
NM_003590.5
p.L268P
c.803T>C
2 papers
NM_003590.5
p.L268delFs
c.802delG
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