Varaico: Literature-Extracted Genetic Variants

Gene:CUL3
Variant:p.T256M

CUL3

494 papers

RefSeq Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core compo...

Pfam Domains

Cullinaa 34–484UCSCCullin alpha solenoid domain
Cullin_ABaa 507–665UCSCCullin alpha+beta domain
Cullin_Nedd8aa 698–760UCSCCullin protein neddylation domain

Gene Aliases

HGNC Name

cullin 3

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003590.5
p.T256M
c.767C>T
Surrounding Variants
1 paper
NM_003590.5
p.E257fs
c.769_770fs
2 papers
NM_003590.5
p.S255*
c.764C>G
2 papers
NM_003590.5
p.S255*
c.764C>A
1 paper
NM_003590.5
p.E257delFs
c.769delC
1 paper
NM_003590.5
p.P259S
c.775C>T
1 paper
NM_003590.5
p.P259insFs
c.776_777insA
1 paper
NM_003590.5
p.I260F
c.778A>T
1 paper
NM_003590.5
p.I260V
c.778A>G
1 paper
NM_003590.5
p.C251R
c.751T>C
1 paper
NM_003590.5
p.H250R
c.749A>G
2 papers
NM_003590.5
p.M249I
c.747G>T
2 papers
NM_003590.5
p.M249I
c.747G>C
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