Varaico: Literature-Extracted Genetic Variants

Gene:CXCR2
Variant:p.M250L

CXCR2

226 papers

RefSeq Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal...

Pfam Domains

7tm_1aa 65–314UCSC7 transmembrane receptor (rhodopsin family)

Gene Aliases

HGNC Name

C-X-C motif chemokine receptor 2

HGNC Previous Symbol

IL8RB

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_001557.4
p.M250L
c.748A>C
Surrounding Variants
2 papers
NM_001557.4
p.M250L
c.748A>T
1 paper
NM_001557.4
p.R251Q
c.752G>A
7 papers
NM_001557.4
p.R248Q
c.743G>A
2 papers
NM_001557.4
p.R248W
c.742C>T
1 paper
NM_001557.4
p.V252F
c.754G>T
1 paper
NM_001557.4
p.Q245H
c.735G>C
1 paper
NM_001557.4
p.Q245H
c.735G>T
5 papers
NM_001557.4
p.V256V
c.768C>T
2 papers
NM_001557.4
p.A241T
c.721G>A
1 paper
NM_001557.4
p.I259M
c.777C>G
1 paper
NM_001557.4
p.K240_M243delFs
c.720_727del8
3 papers
NM_001557.4
p.L261L
c.781C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."