Varaico: Literature-Extracted Genetic Variants

DDR2

688 papers

RefSeq Summary

This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironme...

Pfam Domains

F5_F8_type_Caa 45–182UCSCF5/8 type C domain

DDR1-2_DS-likeaa 190–366UCSCDiscoidin domain-containing receptor 1/2, DS-like domain

PK_Tyr_Ser-Thraa 563–849UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

discoidin domain receptor tyrosine kinase 2

HGNC Previous Symbols

TYRO10; NTRKR3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006182.4

p.I488M

c.1464A>G

Surrounding Variants

3 papers

NM_006182.4

p.R489*

c.1465C>T

1 paper

NM_006182.4

p.I488L

c.1462A>C

1 paper

NM_006182.4

p.I488L

c.1462A>T

1 paper

NM_006182.4

p.R489Q

c.1466G>A

2 papers

NM_006182.4

p.R489L

c.1466G>T

1 paper

NM_006182.4

p.R486S

c.1458G>C

1 paper

NM_006182.4

p.R486S

c.1458G>T

1 paper

NM_006182.4

p.S485S

c.1455C>A

1 paper

NM_006182.4

p.P492T

c.1474C>A

3 papers

NM_006182.4

p.P492S

c.1474C>T

2 papers

NM_006182.4

p.S485F

c.1454C>T

1 paper

NM_006182.4

p.P492Q

c.1475C>A