Varaico: Literature-Extracted Genetic Variants

DDR2

688 papers

RefSeq Summary

This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironme...

Pfam Domains

F5_F8_type_Caa 45–182UCSCF5/8 type C domain

DDR1-2_DS-likeaa 190–366UCSCDiscoidin domain-containing receptor 1/2, DS-like domain

PK_Tyr_Ser-Thraa 563–849UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

discoidin domain receptor tyrosine kinase 2

HGNC Previous Symbols

TYRO10; NTRKR3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006182.4

p.V748L

c.2242G>T

Surrounding Variants

1 paper

NM_006182.4

p.V748L

c.2242G>C

1 paper

NM_006182.4

p.A747T

c.2239G>A

2 papers

NM_006182.4

p.A747_W753del0

c.2240_2257del18

2 papers

NM_006182.4

p.R746Q

c.2237G>A

1 paper

NM_006182.4

p.R746L

c.2237G>T

1 paper

NM_006182.4

p.R746W

c.2236C>T

1 paper

NM_006182.4

p.R746_P750del0

c.2236_2250del15

3 papers

NM_006182.4

p.G745_P750del0

c.2235_2249del15

1 paper

NM_006182.4

p.R752S

c.2254C>A

17 papers

NM_006182.4

p.R752C

c.2254C>T

1 paper

NM_006182.4

p.I743M

c.2229C>G

8 papers

NM_006182.4

p.R752H

c.2255G>A