DENN domain containing 1A

KIAA1608

FLJ21129

FAM31A

DENN/MADD domain containing 1A

connecdenn 1

DENN domain-containing protein 1A

Connecdenn 1

Protein FAM31A

Connecdenn

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010].

Varaico: Literature-Extracted Genetic Variants

DENND1A

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol