DENN domain containing 1B

FAM31B

C1orf218

MGC27044

FLJ20054

family with sequence similarity 31, member B

chromosome 1 open reading frame 218

DENN/MADD domain containing 1B

connecdenn 2

DENN domain-containing protein 1B

Connecdenn 2

Protein FAM31B

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010].

Varaico: Literature-Extracted Genetic Variants

DENND1B

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbols