DENN domain containing 2B

HTS1

p126

suppression of tumorigenicity 5

DENN/MADD domain containing 2B

HeLa tumor suppression

DENN domain-containing protein 2B

HeLa tumor suppression 1

Suppression of tumorigenicity 5 protein

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

DENND2B

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol