Varaico: Literature-Extracted Genetic Variants

Gene:DHFR
Variant:p.Q141K

DHFR

423 papers

RefSeq Summary

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the function...

Pfam Domains

DHFR_1aa 4–126UCSCDihydrofolate reductase

Gene Aliases

HGNC Name

dihydrofolate reductase

HGNC Alias Symbol

DHFR1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
5 papers
NM_000791.4
p.Q141K
c.421C>A
Surrounding Variants
1 paper
NM_000791.4
p.Q141*
c.421C>T
1 paper
NM_000791.4
p.D142Y
c.424G>T
1 paper
NM_000791.4
p.I139I
c.417C>T
1 paper
NM_000791.4
p.I139T
c.416T>C
1 paper
NM_000791.4
p.M140_F143ins1
c.420_428dup9
1 paper
NM_000791.4
p.R138K
c.413G>A
1 paper
NM_000791.4
p.E144K
c.430G>A
2 papers
NM_000791.4
p.T137R
c.410C>G
1 paper
NM_000791.4
p.T137A
c.409A>G
1 paper
NM_000791.4
p.S145insFs
c.434_435ins11
1 paper
NM_000791.4
p.V136A
c.407T>C
1 paper
NM_000791.4
p.D146N
c.436G>A
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