Varaico: Literature-Extracted Genetic Variants

Gene:DHFR
Variant:p.I61V

DHFR

423 papers

RefSeq Summary

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the function...

Pfam Domains

DHFR_1aa 4–126UCSCDihydrofolate reductase

Gene Aliases

HGNC Name

dihydrofolate reductase

HGNC Alias Symbol

DHFR1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_000791.4
p.I61V
c.181A>G
Surrounding Variants
2 papers
NM_000791.4
p.I61ins3
c.181_182ins9
1 paper
NM_000791.4
p.S60S
c.180C>T
1 paper
NM_000791.4
p.S60S
c.180C>A
1 paper
NM_000791.4
p.I61M
c.183T>G
1 paper
NM_000791.4
p.S60F
c.179C>T
2 papers
NM_000791.4
p.S60ins3
c.178_179ins9
2 papers
NM_000791.4
p.S60ins6
c.178_179ins18
1 paper
NM_000791.4
p.P62S
c.184C>T
1 paper
NM_000791.4
p.F59L
c.177C>G
1 paper
NM_000791.4
p.F59L
c.177C>A
1 paper
NM_000791.4
p.F59L
c.175T>C
2 papers
NM_000791.4
p.E63G
c.188A>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."