Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_177438.3

p.R1839W

c.5515C>T

Surrounding Variants

3 papers

NM_177438.3

p.R1839Q

c.5516G>A

1 paper

NM_177438.3

p.R1839R

c.5517G>T

1 paper

NM_177438.3

p.M1837I

c.5511G>T

2 papers

NM_177438.3

p.M1837fs

c.5509_5510fs

1 paper

NM_177438.3

p.M1837I

c.5511G>C

1 paper

NM_177438.3

p.M1837I

c.5511G>A

1 paper

NM_177438.3

p.P1840P

c.5520A>G

2 papers

NM_177438.3

p.L1841L

c.5521C>T

1 paper

NM_177438.3

p.P1836delFs

c.5508delG

6 papers

NM_177438.3

p.Y1835_P1836delFs

c.5504_5507del4

2 papers

NM_177438.3

p.P1836L

c.5507C>T

2 papers

NM_177438.3

p.P1836H

c.5507C>A