Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_177438.3

p.Y1835fs

c.5503_5504fs

Surrounding Variants

2 papers

NM_177438.3

p.Y1835C

c.5504A>G

3 papers

NM_177438.3

p.Y1835S

c.5504A>C

2 papers

NM_177438.3

p.Y1835Y

c.5505T>C

2 papers

NM_177438.3

p.Y1835_P1836insFs

c.5505_5506insT

3 papers

NM_177438.3

p.V1833V

c.5499G>A

2 papers

NM_177438.3

p.P1836L

c.5507C>T

2 papers

NM_177438.3

p.P1836H

c.5507C>A

1 paper

NM_177438.3

p.V1833G

c.5498T>G

6 papers

NM_177438.3

p.Y1835_P1836delFs

c.5504_5507del4

1 paper

NM_177438.3

p.P1836delFs

c.5508delG

1 paper

NM_177438.3

p.Q1832fs

c.5494_5495fs

1 paper

NM_177438.3

p.M1837I

c.5511G>T