Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_177438.3

p.Y1820*

c.5460C>A

Surrounding Variants

2 papers

NM_177438.3

p.Y1820*

c.5460C>G

1 paper

NM_177438.3

p.Y1820N

c.5458T>A

1 paper

NM_177438.3

p.M1821I

c.5463G>T

1 paper

NM_177438.3

p.M1821I

c.5463G>C

1 paper

NM_177438.3

p.M1821I

c.5463G>A

1 paper

NM_177438.3

p.I1819S

c.5456T>G

1 paper

NM_177438.3

p.D1822Y

c.5464G>T

3 papers

NM_177438.3

p.D1822N

c.5464G>A

12 papers

NM_177438.3

p.D1822V

c.5465A>T

2 papers

NM_177438.3

p.D1822G

c.5465A>G

1 paper

NM_177438.3

p.I1819V

c.5455A>G

1 paper

NM_177438.3

p.D1822delFs

c.5464delC