Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_177438.3

p.G1809_D1810delins

c.5427_5428delinsTT

Surrounding Variants

94 papers

NM_177438.3

p.D1810Y

c.5428G>T

1 paper

NM_177438.3

p.D1810Fs

c.5428delinsTTFs

63 papers

NM_177438.3

p.D1810H

c.5428G>C

20 papers

NM_177438.3

p.D1810N

c.5428G>A

1 paper

NM_177438.3

p.G1809fs

c.5425_5426fs

1 paper

NM_177438.3

p.G1809G

c.5427G>A

47 papers

NM_177438.3

p.D1810V

c.5429A>T

14 papers

NM_177438.3

p.D1810G

c.5429A>G

9 papers

NM_177438.3

p.D1810A

c.5429A>C

1 paper

NM_177438.3

p.D1810delins

c.5428_5429delinsAG

2 papers

NM_177438.3

p.D1810fs

c.5428_5429fs

1 paper

NM_177438.3

p.D1810E

c.5430T>G