Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_177438.3

p.E1800E

c.5400G>A

Surrounding Variants

4 papers

NM_177438.3

p.D1801N

c.5401G>A

1 paper

NM_177438.3

p.E1800G

c.5399A>G

3 papers

NM_177438.3

p.E1800Q

c.5398G>C

1 paper

NM_177438.3

p.E1799fs

c.5395_5396fs

1 paper

NM_177438.3

p.E1799*

c.5395G>T

1 paper

NM_177438.3

p.E1799K

c.5395G>A

7 papers

NM_177438.3

p.K1798delFs

c.5394delT

2 papers

NM_177438.3

p.E1799fs

c.5395_5396fs

1 paper

NM_177438.3

p.K1798fs

c.5392_5393fs

2 papers

NM_177438.3

p.E1803K

c.5407G>A

1 paper

NM_177438.3

p.E1803D

c.5409A>T

1 paper

NM_177438.3

p.E1803D

c.5409A>C