Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_177438.3

p.R1790K

c.5369G>A

Surrounding Variants

1 paper

NM_177438.3

p.R1790T

c.5369G>C

1 paper

NM_177438.3

p.R1791I

c.5372G>T

1 paper

NM_177438.3

p.L1789fs

c.5365_5366fs

3 papers

NM_177438.3

p.E1788_L1789Splc

c.5365-1G>T

2 papers

NM_177438.3

p.E1788_L1789Splc

c.5365-1G>C

2 papers

NM_177438.3

p.E1788_L1789Splc

c.5365-1G>A

3 papers

NM_177438.3

p.E1788_L1789Splc

c.5365-2A>G

2 papers

NM_177438.3

p.E1788_L1789Splc

c.5365-4A>G

1 paper

NM_177438.3

p.E1793V

c.5378A>T

1 paper

NM_177438.3

p.E1793D

c.5379G>T

1 paper

NM_177438.3

p.E1793fs

c.5377_5378fs

1 paper

NM_177438.3

p.E1793D

c.5379G>C