Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_177438.3

p.V1773A

c.5318T>C

Surrounding Variants

6 papers

NM_177438.3

p.F1772delFs

c.5315_5316delAA

1 paper

NM_177438.3

p.F1772del1

c.5314_5315delAAA

4 papers

NM_177438.3

p.F1772fs

c.5314_5315fs

1 paper

NM_177438.3

p.Q1774*

c.5320C>T

1 paper

NM_177438.3

p.Q1774K

c.5320C>A

3 papers

NM_177438.3

p.F1772fs

c.5314_5315fs

2 papers

NM_177438.3

p.Q1776*

c.5326C>T

1 paper

NM_177438.3

p.Q1776E

c.5326C>G

1 paper

NM_177438.3

p.L1777I

c.5329C>A

3 papers

NM_177438.3

p.L1777H

c.5330T>A

1 paper

NM_177438.3

p.E1778Q

c.5332G>C

1 paper

NM_177438.3

p.E1778K

c.5332G>A