Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_177438.3

p.P1729P

c.5187G>A

Surrounding Variants

1 paper

NM_177438.3

p.G1730W

c.5188G>T

1 paper

NM_177438.3

p.G1730R

c.5188G>C

1 paper

NM_177438.3

p.G1730R

c.5188G>A

2 papers

NM_177438.3

p.P1729L

c.5186C>T

1 paper

NM_177438.3

p.P1729Q

c.5186C>A

1 paper

NM_177438.3

p.G1730fs

c.5188_5189fs

1 paper

NM_177438.3

p.G1730G

c.5190G>A

2 papers

NM_177438.3

p.S1728F

c.5183C>T

2 papers

NM_177438.3

p.V1731fs

c.5191_5192fs

2 papers

NM_177438.3

p.V1731delFs

c.5191delC

1 paper

NM_177438.3

p.L1732fs

c.5194_5195fs

1 paper

NM_177438.3

p.H1727R

c.5180A>G