Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_177438.3

p.Y1721Y

c.5163T>C

Surrounding Variants

3 papers

NM_177438.3

p.Y1721*

c.5163T>G

3 papers

NM_177438.3

p.Y1721*

c.5163T>A

1 paper

NM_177438.3

p.E1722K

c.5164G>A

1 paper

NM_177438.3

p.H1719H

c.5157C>T

2 papers

NM_177438.3

p.P1724S

c.5170C>T

1 paper

NM_177438.3

p.P1724L

c.5171C>T

1 paper

NM_177438.3

p.K1718N

c.5154G>T

1 paper

NM_177438.3

p.K1718N

c.5154G>C

2 papers

NM_177438.3

p.P1724P

c.5172G>A

1 paper

NM_177438.3

p.P1724delFs

c.5171delG

1 paper

NM_177438.3

p.R1725W

c.5173C>T

1 paper

NM_177438.3

p.E1722_P1724del3

c.5164_5171del9