Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_177438.3

p.I1711M

c.5133T>G

Surrounding Variants

1 paper

NM_177438.3

p.I1711T

c.5132T>C

3 papers

NM_177438.3

p.A1710del1

c.5128_5129delCGC

1 paper

NM_177438.3

p.L1712F

c.5136G>T

1 paper

NM_177438.3

p.L1712F

c.5136G>C

6 papers

NM_177438.3

p.D1713Y

c.5137G>T

1 paper

NM_177438.3

p.D1713H

c.5137G>C

4 papers

NM_177438.3

p.D1713N

c.5137G>A

1 paper

NM_177438.3

p.A1710V

c.5129C>T

8 papers

NM_177438.3

p.G1708_A1710delFs

c.5122_5128del7

1 paper

NM_177438.3

p.A1710S

c.5128G>T

17 papers

NM_177438.3

p.D1713V

c.5138A>T

8 papers

NM_177438.3

p.D1713A

c.5138A>C