Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_177438.3

p.G1708fs

c.5122_5123fs

Surrounding Variants

3 papers

NM_177438.3

p.G1708R

c.5122G>C

3 papers

NM_177438.3

p.G1708R

c.5122G>A

1 paper

NM_177438.3

p.G1708A

c.5123G>C

6 papers

NM_177438.3

p.G1708E

c.5123G>A

1 paper

NM_177438.3

p.G1708fs

c.5122_5123fs

11 papers

NM_177438.3

p.D1709Y

c.5125G>T

8 papers

NM_177438.3

p.D1709H

c.5125G>C

151 papers

NM_177438.3

p.D1709N

c.5125G>A

14 papers

NM_177438.3

p.D1709V

c.5126A>T

52 papers

NM_177438.3

p.D1709G

c.5126A>G

13 papers

NM_177438.3

p.D1709A

c.5126A>C

1 paper

NM_177438.3

p.D1709delins

c.5125_5126delinsTG