Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_177438.3

p.E1705D

c.5115A>C

Surrounding Variants

2 papers

NM_177438.3

p.E1705D

c.5115A>T

17 papers

NM_177438.3

p.E1705V

c.5114A>T

6 papers

NM_177438.3

p.E1705A

c.5114A>C

2 papers

NM_177438.3

p.E1705*

c.5113G>T

14 papers

NM_177438.3

p.E1705Q

c.5113G>C

131 papers

NM_177438.3

p.E1705K

c.5113G>A

1 paper

NM_177438.3

p.L1704F

c.5112A>T

1 paper

NM_177438.3

p.L1704F

c.5112A>C

1 paper

NM_177438.3

p.L1704V

c.5110T>G

3 papers

NM_177438.3

p.G1708R

c.5122G>C

3 papers

NM_177438.3

p.G1708R

c.5122G>A

4 papers

NM_177438.3

p.G1708fs

c.5122_5123fs