Varaico: Literature-Extracted Genetic Variants

DICER1

1,122 papers

RefSeq Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and i...

Pfam Domains

DEADaa 45–213UCSCDEAD/DEAH box helicase

Dicer_PBDaa 267–367UCSCDicer, partner-binding domain

Helicase_Caa 471–555UCSCHelicase conserved C-terminal domain

Dicer_dimeraa 630–719UCSCDicer dimerisation domain

Dicer_platformaa 761–887UCSCDicer, platform domain

PAZaa 894–1064UCSCPAZ domain

Gene Aliases

HGNC Name

dicer 1, ribonuclease III

HGNC Previous Symbol

MNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_177438.3

p.Y1701*

c.5103C>A

Surrounding Variants

7 papers

NM_177438.3

p.Y1701*

c.5103C>G

9 papers

NM_177438.3

p.Q1702*

c.5104C>T

1 paper

NM_177438.3

p.Q1702E

c.5104C>G

1 paper

NM_177438.3

p.Y1701H

c.5101T>C

1 paper

NM_177438.3

p.Y1701fs

c.5101_5102fs

1 paper

NM_177438.3

p.Q1702L

c.5105A>T

1 paper

NM_177438.3

p.C1700W

c.5100T>G

3 papers

NM_177438.3

p.R1703C

c.5107C>T

1 paper

NM_177438.3

p.R1703S

c.5107C>A

1 paper

NM_177438.3

p.L1704V

c.5110T>G

3 papers

NM_177438.3

p.D1699fs

c.5095_5096fs

4 papers

NM_177438.3

p.D1699Splc

c.5096-1G>T