Varaico: Literature-Extracted Genetic Variants

DKK1

160 papers

RefSeq Summary

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The en...

Pfam Domains

Dickkopf_Naa 84–139UCSCDickkopf N-terminal cysteine-rich region

DIKK1-2-4_C-subdom1aa 185–214UCSCDickkopf-related protein 1/2/4, C-terminal subdomain 1

DIKK1-2-4_C-subdom2aa 217–266UCSCDickkopf-related protein 1/2/4, C-terminal subdomain 2

Gene Aliases

HGNC Name

dickkopf Wnt signaling pathway inhibitor 1

HGNC Alias Symbols

SK; DKK-1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_012242.4

p.H251ins2

c.752_753ins6

Surrounding Variants

1 paper

NM_012242.4

p.Q253R

c.758A>G

1 paper

NM_012242.4

p.Q248*

c.742C>T

1 paper

NM_012242.4

p.R246Q

c.737G>A

1 paper

NM_012242.4

p.S244Y

c.731C>A

1 paper

NM_012242.4

p.S258Y

c.773C>A

1 paper

NM_012242.4

p.C263R

c.787T>C

1 paper

NM_012242.4

p.E232A

c.695A>C

2 papers

NM_012242.4

p.E232K

c.694G>A

1 paper

NM_012242.4

p.G230R

c.688G>A

1 paper

NM_012242.4

p.G230R

c.688G>C

1 paper

NM_012242.4

p.H229H

c.687T>C

1 paper

NM_012242.4

p.R225S

c.675A>C