Varaico: Literature-Extracted Genetic Variants

DNMT3B

501 papers

RefSeq Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required...

Pfam Domains

PWWPaa 226–310UCSCPWWP domain

ADD_DNMT3aa 416–471UCSCDNMT3, cysteine rich ADD domain, GATA1-like zinc finger

DNMT3_ADD_GATA1-likeaa 478–527UCSCDNMT3, ADD PHD zinc finger

DNA_methylaseaa 575–722UCSCC-5 cytosine-specific DNA methylase

Gene Aliases

HGNC Name

DNA methyltransferase 3 beta

HGNC Previous Name

DNA (cytosine-5-)-methyltransferase 3 beta

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006892.4

p.A569T

c.1705G>A

Surrounding Variants

1 paper

NM_006892.4

p.A570G

c.1709C>G

1 paper

NM_006892.4

p.A570V

c.1709C>T

1 paper

NM_006892.4

p.R571*

c.1711C>T

1 paper

NM_006892.4

p.R572K

c.1715G>A

1 paper

NM_006892.4

p.L563V

c.1687C>G

1 paper

NM_006892.4

p.K562T

c.1685A>C

1 paper

NM_006892.4

p.R576*

c.1726C>T

1 paper

NM_006892.4

p.S579T

c.1735T>A

3 papers

NM_006892.4

p.G583S

c.1747G>A

1 paper

NM_006892.4

p.I584V

c.1750A>G

5 papers

NM_006892.4

p.A585T

c.1753G>A

10 papers

NM_006892.4

p.A585V

c.1754C>T