Varaico: Literature-Extracted Genetic Variants

DNMT3B

501 papers

RefSeq Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required...

Pfam Domains

PWWPaa 226–310UCSCPWWP domain

ADD_DNMT3aa 416–471UCSCDNMT3, cysteine rich ADD domain, GATA1-like zinc finger

DNMT3_ADD_GATA1-likeaa 478–527UCSCDNMT3, ADD PHD zinc finger

DNA_methylaseaa 575–722UCSCC-5 cytosine-specific DNA methylase

Gene Aliases

HGNC Name

DNA methyltransferase 3 beta

HGNC Previous Name

DNA (cytosine-5-)-methyltransferase 3 beta

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006892.4

p.A844T

c.2530G>A

Surrounding Variants

1 paper

NM_006892.4

p.F843F

c.2529C>T

1 paper

NM_006892.4

p.P845S

c.2533C>T

13 papers

NM_006892.4

p.R840Q

c.2519G>A

1 paper

NM_006892.4

p.R840*

c.2518C>T

6 papers

NM_006892.4

p.V836M

c.2506G>A

NM_001207056.2

p.V677M

c.2029G>A

4 papers

NM_006892.4

p.R826H

c.2477G>A

1 paper

NM_006892.4

p.R826L

c.2477G>T

8 papers

NM_006892.4

p.R826C

c.2476C>T

1 paper

NM_006892.4

p.A825V

c.2474C>T

2 papers

NM_006892.4

p.R823H

c.2468G>A

2 papers

NM_006892.4

p.R823P

c.2468G>C

9 papers

NM_006892.4

p.R823G

c.2467C>G