Varaico: Literature-Extracted Genetic Variants

DROSHA

357 papers

RefSeq Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA...

Pfam Domains

Helical_CED_Droshaaa 718–850UCSCRibonuclease 3, central domain, two antiparallel helical region

Ribonucleas_3_3aa 957–1072UCSCRibonuclease-III-like

Ribonuclease_3aa 1144–1233UCSCRibonuclease III domain

dsrmaa 1261–1332UCSCDouble-stranded RNA binding motif

Gene Aliases

HGNC Name

drosha ribonuclease III

HGNC Previous Symbol

RNASEN

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001382508.1

p.D973H

c.2917G>C

Surrounding Variants

2 papers

NM_001382508.1

p.D973N

c.2917G>A

1 paper

NM_001382508.1

p.D973E

c.2919T>G

1 paper

NM_001382508.1

p.D973E

c.2919T>A

1 paper

NM_001382508.1

p.A974V

c.2921C>T

1 paper

NM_001382508.1

p.E969G

c.2906A>G

1 paper

NM_001382508.1

p.E969K

c.2905G>A

5 papers

NM_001382508.1

p.R967W

c.2899C>T

1 paper

NM_001382508.1

p.L979M

c.2935C>A

1 paper

NM_001382508.1

p.R961Splc

c.2883-1G>A

1 paper

NM_001382508.1

p.S981Splc

c.2942+306G>A

2 papers

NM_001382508.1

p.S990R

c.2968A>C

1 paper

NM_001382508.1

p.S990I

c.2969G>T