Varaico: Literature-Extracted Genetic Variants

DROSHA

357 papers

RefSeq Summary

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA...

Pfam Domains

Helical_CED_Droshaaa 718–850UCSCRibonuclease 3, central domain, two antiparallel helical region

Ribonucleas_3_3aa 957–1072UCSCRibonuclease-III-like

Ribonuclease_3aa 1144–1233UCSCRibonuclease III domain

dsrmaa 1261–1332UCSCDouble-stranded RNA binding motif

Gene Aliases

HGNC Name

drosha ribonuclease III

HGNC Previous Symbol

RNASEN

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001382508.1

p.R371H

c.1112G>A

Surrounding Variants

1 paper

NM_001382508.1

p.W372*

c.1115G>A

1 paper

NM_001382508.1

p.D370Y

c.1108G>T

1 paper

NM_001382508.1

p.W372*

c.1116G>A

1 paper

NM_001382508.1

p.E367K

c.1099G>A

1 paper

NM_001382508.1

p.W365*

c.1094G>A

1 paper

NM_001382508.1

p.R364H

c.1091G>A

2 papers

NM_001382508.1

p.R364C

c.1090C>T

1 paper

NM_001382508.1

p.G379S

c.1135G>A

1 paper

NM_001382508.1

p.G379G

c.1137C>G

1 paper

NM_001382508.1

p.R362_A363insT

c.1084_1088ins3

1 paper

NM_001382508.1

p.R358fs

c.1072_1073fs

1 paper

NM_001382508.1

p.P356fs

c.1066_1067fs